The term 'tiresome one' can be described by four crossword solutions: PILL, BORE, DRIP, and PEST. A PILL is a small, usually round object that is meant to be swallowed as medicine. A BORE is someone or something that is dull and uninteresting. A DRIP is someone who talks or behaves in a tedious and annoying way. Finally, a PEST is an annoying person or creature that causes trouble or annoyance. All of these words describe someone who is tiresome and difficult to be around.