The Lyon River is a major river in France, formed by the confluence of the Saône and Rhône rivers. The Saône is a major tributary of the Rhône, which flows south through the city of Lyon and eventually empties into the Mediterranean Sea. The Rhône is the second-longest river in France, and it flows north from the Swiss Alps to the Mediterranean Sea. Together, the Saône and Rhône form the Lyon River, which is an important waterway for transportation and commerce in France.