The term 'The Biggest Little City in the World' is often used to refer to Reno, Nevada. Reno is a city in the western United States, located in the state of Nevada. It is known for its casinos and nightlife, and is often referred to as the 'Biggest Little City in the World' due to its small size but large population. Reno is also home to the University of Nevada, Reno, and is a popular tourist destination.