PITH is a term used to describe the most essential part of something, usually referring to the innermost or central part. SIGNIFICANCE (12 letters) is the IMPORTANCE or value of something, while IMPORT (6 letters) is the act of bringing something into a place or situation. CONSEQUENCE (11 letters) is the result or outcome of an action or event, and SUBSTANCE (9 letters) is the material or ESSENCE of something. CRUX (4 letters) is the most important point of an argument or problem, and QUINTESSENCE (12 letters) is the purest and most concentrated form of something. KERNEL (6 letters) is the innermost or essential part of something, while INTERIOR (8 letters) is the inside or inner part of something. FORTITUDE (9 letters) is courage in pain or adversity, and HEART (5 letters) is the innermost or central part of something. BODY (4 letters) is the physical structure of a person or animal, while MEANING (7 letters) is the purpose or SIGNIFICANCE of something. NUB (3 letters) is the essential or most important part of something, and CENTER (6 letters) is the middle point of something. ENERGY (6 letters) is the STRENGTH and vitality required for sustained physical or mental activity, while IMPORTANCE (10 letters) is the quality of being significant or worthy of attention. STRENGTH (8 letters) is the power or ability to resist force or pressure, and CORE (4 letters) is the central or innermost part of something. GIST (4 letters) is the main point or ESSENCE of something, while ESSENCE (7 letters) is the intrinsic nature or indispensable quality of something. MEAT (4 letters) is the flesh of an animal used as food, and MARROW (6 letters) is the innermost or essential part of something.