Call it quits' is an idiom that means to STOP doing something, usually because it has become too difficult or too much of a burden. The crossword solutions for this term include 'STOP, ' 'CEASE, ' 'RETIRE, ' 'BREAKUP, ' 'FOLD, ' 'DEMIT, ' 'HALT, ' 'END, ' 'RESIGN, ' 'closeshop, ' 'cashinyourchips, ' 'throwinoneshand, ' 'throwinthetowel, ' and 'turninyourbadge.' All of these words and phrases are related to the idea of ending something, whether it be a job, a relationship, or any other activity.