Washington State is home to four major cities: Spokane (7 letters), Tacoma (6 letters), Seattle (7 letters), and Yakima (6 letters). Spokane is the second largest city in the state and is located in the eastern part of Washington. Tacoma is located in the south-central part of the state and is the third largest city. Seattle is the largest city in the state and is located in the western part of Washington. Yakima is located in the south-central part of the state and is the fourth largest city.