The crossword solutions for the term SUFFIXES WITH DEPEND AND DIFFER are ENCES (5 letters). Suffixes are word endings that are added to the end of a root word to change its meaning. Depend and differ are two different suffixes that can be used to modify the meaning of a root word. The suffix depend means to rely on or be determined by something, while the suffix differ means to be unlike or distinct from something. The solution ENCES is a combination of these two suffixes, and it can be used to describe something that is both dependent and different.