The crossword solution for the term SUFFIX WITH HARLEM is 'ITE'. This suffix is commonly used to form adjectives and nouns from verbs. It is derived from the Old English verb ending '-ite', which was used to form the past participle of verbs. The term 'Harlem' is a neighborhood in the northern part of Manhattan, New York City. It is known for its rich cultural history and vibrant African-American community.