Stomach discomfort is a common ailment that can be caused by a variety of factors. It is characterized by a feeling of unease or pain in the abdomen, and can range from mild to severe. The crossword solutions for this term are ACHE (4 letters), AGITA (5 letters), and KNOT (4 letters). ACHE is a dull, continuous pain, AGITA is an Italian-American slang term for indigestion, and KNOT is a tight, hard lump in the stomach. All three words describe the physical sensations associated with stomach discomfort.