The crossword solution for the term 'state of misfortune or affliction' is 'HARDSHIP'. HARDSHIP is a difficult situation or condition that is caused by poverty, illness, or other factors. It can refer to a lack of basic necessities such as food, shelter, and clothing, or it can refer to a more general feeling of distress or suffering. HARDSHIP can also refer to a state of emotional or mental distress caused by difficult circumstances.