State of Distress is a term used to describe a situation of extreme hardship or suffering. It is often used to refer to a state of physical, mental, or emotional distress caused by difficult circumstances. The term can also be used to describe a state of financial or political distress. In the crossword, the 10-letter solution for State of Distress is AFFLICTION, which is defined as a state of great suffering or distress due to adversity or misfortune.