The term 'SPOTS TO CLEAR UP' can be solved by the four-letter word 'ACNE'. ACNE is a common skin condition that affects many people, especially during adolescence. It is caused by an overproduction of oil in the skin, which can lead to clogged pores and the formation of spots. Treatment for ACNE usually involves topical creams or antibiotics, as well as lifestyle changes such as avoiding certain foods and stress management.