The South American region is made up of two distinct areas: GUIANA and Patagonia. GUIANA is a six-letter word that refers to the region in the northeast of South America, which includes the countries of Guyana, Suriname, French GUIANA, and parts of Venezuela, Brazil, and Colombia. Patagonia is a nine-letter word that refers to the region in the south of South America, which includes parts of Argentina and Chile. Both regions are known for their diverse landscapes, ranging from tropical rainforests to rugged mountains.