The term 'Soothing Substance' can be defined by the following crossword solutions: Aloe (4 letters), BALM (4 letters), SALVE (5 letters), TALC (4 letters), and Nard (4 letters). Aloe is a plant extract that is often used in skin care products to soothe and moisturize the skin. BALM is a type of ointment that is used to treat minor skin irritations and wounds. SALVE is a type of ointment that is used to treat skin conditions such as eczema and psoriasis. TALC is a mineral that is often used in baby powder to absorb moisture and reduce friction. Nard is an essential oil that is used to reduce inflammation and promote relaxation. All of these substances are used to provide a soothing effect on the skin.