The sixth step in the twelve-step program is to become willing to have God remove all of one's character defects. The fourth letter in this term is 'I', and the answer to the crossword puzzle is 'BIAS'. BIAS is an inclination or prejudice for or against one person or group, especially in a way considered to be unfair. In the context of the twelve-step program, it refers to any negative thoughts or feelings that may be preventing one from achieving spiritual growth.