The five letter answer to the crossword clue 'Shakespearean title characters' is 'wives'. This refers to the female characters in Shakespeare's plays who are married or betrothed, such as Juliet from Romeo and Juliet, Desdemona from Othello, and Lady Macbeth from Macbeth. These characters often have complex relationships with their husbands and other characters in the play, and their stories often end tragically.