The crossword solution for the term SERPENT IN 'ANTONY AND CLEOPATRA' is ASP. In William Shakespeare's play Antony and Cleopatra, the serpent is a metaphor used to describe the character of Cleopatra. She is described as a 'serpent of old Nile' in Act II, Scene V, and is compared to the mythical snake-like creature that guards the Garden of Eden. The serpent is also used to symbolize her power and influence over Antony.