San Francisco, for one, is a major city in California located on the San Francisco BAY. It is the fourth most populous city in the state and the 13th most populous in the United States. The city is known for its iconic landmarks such as the Golden Gate Bridge, Alcatraz Island, and cable cars. The city's nickname is 'The City by the BAY, ' which is derived from its location on the BAY, which is represented by the crossword solution 'BAY.'