River City on the Arno is a reference to the city of Pisa (4 letters) and Florence (8 letters). Pisa is a city in Tuscany, Italy, located on the Arno River. It is most famous for its iconic leaning tower, which is a symbol of the city. Florence is also located in Tuscany, Italy, and is situated on the Arno River. It is known for its art and architecture, and is considered the birthplace of the Renaissance.