The Rhone River is a major river in Europe that flows through Switzerland, France, and into the Mediterranean Sea. Two cities located on the Rhone River are Lyon and ARLES. Lyon is a city in east-central France and is the third-largest city in the country. It is known for its historical and architectural landmarks. ARLES is a city in southern France and is located at the point where the Rhone splits into two branches. It is known for its Roman and Romanesque monuments.