Amen' is a word used in many religious contexts to express agreement or affirmation with a statement or prayer. It is commonly uttered at the end of a sermon as a response from the congregation. The term 'AMEN' is a four letter word commonly used in religious contexts to express agreement or affirmation with a statement or prayer. It is often uttered at the end of a sermon as a response from the congregation, signifying their agreement with the message of the sermon.