The term OPERATE; MANAGE can be summarized as running and managing a business or organization. The crossword solution for this term is RUN, which implies the need to take charge of a business or organization and ensure that it is functioning properly. This includes making sure that all operations are running smoothly, that resources are being used efficiently, and that goals are being met. It also involves making decisions about how the business should be RUN and managed, as well as overseeing the day-to-day activities of the business.