The term ONE, UP FRONT can be broken down into two crossword solutions: MONO (4 letters) and UNI (3 letters). MONO is derived from the Greek word 'monos' meaning 'ALONE' or 'SINGLE'. It is often used to describe something that is SINGLE or ONE of a kind. UNI is derived from the Latin word 'unus' meaning 'ONE'. It is often used to describe something that is singular or unique. Together, the two words form the phrase ONE, UP FRONT, which is used to describe something that is upfront and direct.