One of the Bushes is a reference to the Bush family, which has been prominent in American politics for generations. The two most well-known members of the family are former President George H.W. Bush and his son, former President George W. Bush. JEB is an acronym for John Ellis Bush, the younger brother of George W. Bush and the 43rd Governor of Florida from 1999 to 2007. Laura is an acronym for Laura Welch Bush, the wife of George W. Bush and the former First Lady of the United States from 2001 to 2009.