The term 'ONE MAY BE BITTER' can be solved by the crossword solutions END and PILL. The phrase 'one may be bitter' is often used to describe a person who has experienced a difficult situation or a feeling of disappointment. The word 'END' can refer to the conclusion of something, while the word 'PILL' can refer to a medicine that is taken to treat an illness or condition. Together, these two words suggest that a difficult situation or feeling of disappointment can be overcome with the help of medicine.