Oh, Brother!' is an expression of exasperation or surprise that is often used when something unexpected or unpleasant happens. The crossword solutions for this term are MAN (3 letters), GEEZ (4 letters), SHEESH (6 letters), OYVEY (5 letters), and HEREWEGOAGAIN (13 letters). These words are all exclamations of surprise or frustration, and they are often used in response to a difficult situation.