The term 'Noble Italian Family Name' can be summarized by two crossword solutions: Este (4 letters) and Medici (6 letters). The House of Este was a noble family from the 11th century that ruled over Ferrara, Modena, and Reggio in northern Italy. The House of Medici was a powerful and influential Florentine family from the 13th to 17th centuries. They were patrons of the arts and played a significant role in the development of the Italian Renaissance.