The term 'Native of Mecca' can be summarized by the crossword solution 'ARAB', which is a four letter word. An ARAB is someone who speaks Arabic and is from the Middle East, specifically from the Arabian Peninsula. Arabs are typically associated with the Islamic faith, and Mecca is a holy city in Saudi Arabia that is considered the birthplace of the Prophet Muhammad and is the holiest site in Islam. Therefore, a Native of Mecca would be an ARAB who was born and raised in the city of Mecca.