The term 'make unhappy' can be expressed in a variety of ways, such as 'SADDEN' (6 letters), 'HURT' (4 letters), 'AGGRAVATE' (9 letters), 'IRK' (3 letters), 'UPSET' (5 letters), 'CURDLE' (6 letters), and 'CHAGRIN' (7 letters). These words all describe the act of making someone feel unhappy, either through physical or emotional pain, frustration, or disappointment. Additionally, 'EXASPERATE' (10 letters) is used to describe the act of making someone angry or annoyed.