The term 'make indifferent' can be summarized by the crossword solution 'ALIENATE', which is an 8-letter word. ALIENATE means to cause someone to become unfriendly or unsympathetic, often by isolating them from others. It can also mean to cause someone to feel estranged or disconnected from their own emotions or environment. Alienation is a common theme in literature and art, as it can be used to explore feelings of loneliness and disconnection.