The largest city of Alaska is ANCHORAGE, which has a population of over 300, 000 people. It is the most populous city in the state and is located in the south-central part of the state on the Cook Inlet. ANCHORAGE is the economic and transportation hub of Alaska, with its port being the busiest in the state. It is also home to many cultural attractions, such as the Alaska Native Heritage Center and the ANCHORAGE Museum.