The largest city of Africa is CAIRO, which is the capital of Egypt. It is located on the Nile River and is one of the oldest cities in the world, with a history that dates back to the 10th century BC. It is the most populous city in Africa, with an estimated population of over 9 million people. CAIRO is a major cultural and economic hub for the continent, and is home to many important landmarks, including the Great Pyramids of Giza and the Egyptian Museum.