The two crossword solutions for the term 'Large Mediterranean Island' are CRETE (5 letters) and Sicily (6 letters). CRETE is the largest and most populous of the Greek islands, located in the Mediterranean Sea. It is known for its rich history and culture, as well as its beautiful beaches and mountainous terrain. Sicily is the largest island in the Mediterranean Sea, located off the coast of Italy. It is known for its diverse landscape, ranging from rugged mountains to sandy beaches, and its vibrant culture, with influences from both Europe and North Africa.