The term 'Large City in Nebraska' can be answered with the crossword solution 'OMAHA' (5 letters). Omaha is the largest city in the state of Nebraska, located on the Missouri River along the border with Iowa. It is the county seat of Douglas County and is home to over 446, 000 people. Omaha is a major business hub and cultural center, hosting several Fortune 500 companies and numerous museums, theaters, and other attractions.