Holy guacamole is an exclamation of surprise or amazement. It is often used to express shock, awe, or disbelief. The crossword solutions for the term 'holy guacamole' are WOW (3 letters), YOWZA (5 letters), GOSH (4 letters), WOWIE (5 letters), EGAD (4 letters), and SHEESH (6 letters). All of these words are informal expressions of surprise or amazement, and they are often used in place of more traditional exclamations such as 'goodness gracious!' or 'oh my!'.