The term 'Hit Home With' can be summarized by the crossword solution 'AFFECT, ' which is a 6-letter word. AFFECT is a verb that means to have an influence on someone or something, often in a strong or emotional way. It is often used to describe how a person's feelings or actions are influenced by an event or situation. For example, a person may be affected by a tragedy in their community, or a decision made by a government official may AFFECT the lives of many people.