The phrase 'Here We Go Again' is often used to express exasperation or resignation when faced with a situation that has happened before. The crossword solutions UGH, SIGH, OHNO, OHBOY, and OHBROTHER all reflect this sentiment. UGH is an expression of annoyance, SIGH conveys a sense of weariness, OHNO expresses dismay, OHBOY is a sarcastic expression of resignation, and OHBROTHER is a humorous way of expressing frustration.