Heparin Target is a term used to describe the action of the anticoagulant drug heparin, which works by targeting and inhibiting clotting factors in the blood. CLOT, the four-letter crossword solution, is a term used to describe the formation of a mass of solid material within the body, usually composed of red blood cells, platelets, and fibrin. Heparin works to prevent this from occurring by targeting and inhibiting clotting factors in the blood.