The term 'GIVE IT UP' can be solved by the crossword solutions DESIST (6 letters), CLAP (4 letters), and CEDE (4 letters). DESIST means to stop doing something, CLAP means to strike the palms of the hands together as an expression of approval or celebration, and CEDE means to give up possession or control of something. Together, these words suggest that the phrase 'GIVE IT UP' is asking someone to stop doing something, express approval, and give up control.