DOPE UP is a slang term meaning to make something better or more attractive. The two crossword solutions for this term are DEBASE (6 letters) and ADULTERATE (10 letters). DEBASE means to lower in quality or value, while ADULTERATE means to make impure by adding inferior or tainted substances. Therefore, DOPE UP can be interpreted as making something better or more attractive by lowering its quality or value, or by adding superior substances.