Deep sorrow is an intense emotion of sadness and despair. It is often associated with feelings of loss, regret, and hopelessness. HEARTACHE and GRIEF are two words that are commonly used to describe deep sorrow. HEARTACHE is a feeling of intense emotional pain or distress caused by the loss of someone or something that was once cherished. GRIEF is an intense emotional response to a loss, typically involving feelings of sadness, despair, and longing.