The crossword solution for the term DE ___: FROM SQUARE ONE is 'NOVO', a four-letter word. The phrase 'from square one' is used to refer to starting something from the beginning, or starting over. It is often used when referring to a project or task that has been unsuccessful and needs to be restarted. The Latin phrase 'de novo' literally translates to 'from new' and is used in the same context as 'from square one'.