The two crossword solutions for the term 'Crème de ___ (liqueur)' are CACAO and Cassis. CACAO is a type of liqueur made from cocoa beans, which are the seeds of the CACAO tree. It is usually sweet and creamy, and has a chocolate flavor. Cassis is a type of liqueur made from blackcurrants, which are small, dark-colored berries. It is usually sweet and tart, and has a fruity flavor. Both CACAO and Cassis are popular ingredients in cocktails and other drinks.