The Colombian Cartel City is Cali, a four-letter word. Cali is the capital of the Valle del Cauca department in Colombia and is the third-largest city in the country. It is known for its vibrant culture and nightlife, as well as its association with the Colombian drug trade. The city is home to the powerful Cali Cartel, which was one of the most powerful drug trafficking organizations in the world during the late 20th century.