The term 'College Town in Iowa' can be solved by the four-letter word 'AMES'. AMES is a city located in the central part of the U.S. state of Iowa in Story County. It is best known as the home of Iowa State University, with leading agriculture, engineering, and veterinary medicine programs. AMES is the largest city in Story County and the sixth largest city in Iowa. It is located approximately 30 miles (48 km) north of Des Moines, and it had a population of 66, 191 as of the 2019 U.S. Census estimate.