The two crossword solutions for the term CITY WITH A PENN STATE CAMPUS are Erie (4 letters) and ALTOONA (7 letters). Erie is a city in northwestern Pennsylvania on the shore of Lake Erie. It is the fourth-largest city in the state and the largest city in Northwestern Pennsylvania. ALTOONA is a city in central Pennsylvania, located about 90 miles east of Pittsburgh. It is the principal city of the ALTOONA Metropolitan Statistical Area and is home to the main campus of Penn State ALTOONA.