The term CITY ON THE TRUCKEE RIVER is answered by the crossword solution RENO, which is a four-letter word. Reno is a city in the U.S. state of Nevada, located on the eastern side of the Sierra Nevada mountain range. It is situated along the Truckee River, at the foot of the Sierra Nevada, about 22 miles from Lake Tahoe. Reno is the most populous city in Nevada and the county seat of Washoe County. It is known for its casinos and entertainment, and is a popular tourist destination.