Cincinnati is a city on the Ohio River in southwestern Ohio, with a population of over 300, 000. Evansville is a city on the Ohio River in southwestern Indiana, with a population of over 120, 000. AKRON is a city on the Little Cuyahoga River in northeastern Ohio, with a population of over 200, 000. Reds is the nickname of the Major League Baseball team based in Cincinnati. CAIRO is a city on the Ohio River in southern Illinois, with a population of over 2, 800. Louisville is a city on the Ohio River in Kentucky, with a population of over 600, 000. PaducahKentucky is a city on the Ohio River in western Kentucky, with a population of over 25, 000.