The city of Amarillo, which has 8 letters, is located on the historic Route 66. It is a major city in the Texas Panhandle region and is known for its rich history and culture. The city is also home to many attractions, including the Cadillac Ranch, Palo Duro Canyon State Park, and the Big Texan Steak Ranch. Route 66, which runs through Amarillo, is an iconic highway that was once a major thoroughfare for travelers from Chicago to Los Angeles.