The term CITY IOWA is composed of two crossword solutions, SIOUX (5 letters) and AMES (4 letters). SIOUX City is the fourth largest city in Iowa, located in the northwest corner of the state. It is known for its historical sites, such as the Sergeant Floyd Monument, which commemorates the Lewis and Clark Expedition. AMES is a city located in central Iowa, and is home to Iowa State University. It is known for its vibrant culture, with many festivals and events held throughout the year.